Studies

CellWell record HH-99007

Alterations of short-chain fatty acids in depression and effects of probiotics/prebiotics interventions on levels and clinical symptoms: a systematic review and meta-analysis

Li J; Liu H; Wang M; Dong K; Guo R

2026

In plain language

Pooling studies of major depressive disorder, circulating acetate, propionate, butyrate and valerate were lower than in controls, faecal patterns differed, and probiotic or prebiotic interventions only partly shifted faecal short-chain fatty acids.

Evidence
Emerging

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