Studies

CellWell record HH-95401

Electron transfer across the chromaffin granule membrane. Use of EPR to demonstrate reduction of intravesicular ascorbate radical by the extravesicular mitochondrial NADH:ascorbate radical oxidoreductase

Wakefield LM; Cass AE; Radda GK

The Journal of biological chemistry ยท 1986

In plain language

Using EPR spectroscopy in bovine chromaffin granules, researchers found that extravesicular ascorbate radical increases were mirrored inside resealed granule ghosts but not in plain liposomes, supporting a membrane pathway that recycles ascorbate radical generated during hormone synthesis.

Evidence
Emerging

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