CellWell record HH-79105
Reducing sialylation in melanoma increases classical pathway-mediated complement activation
Magali Coccimiglio; Georgia Clayton; Elisa Toffoli; Tanja de Gruijl; Richard Pouw; Fabrizio Chiodo; Yvette van Kooyk
2026
In plain language
In human melanoma cell lines and patient samples, metabolic or enzymatic reduction of sialylation increased classical pathway complement activation, enhancing C3 opsonization and membrane attack complex formation on tumour cells.
- Evidence
- Emerging
Cite this record: https://thecellwell.org/studies/HH-79105
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