CellWell record HH-78939
GPR107-EGFR crosstalk promotes ovarian cancer metastasis by regulating IL-6 release via PI3K/AKT/NF-κB signaling pathway
Jing Zhao; Xintao Wang; Tiankang Li; Jie Chen; Haiyan Zhu; Liang Yang; Yingchao Liang
2026
In plain language
GPR107 was highly expressed in ovarian cancer and associated with advanced stage, and its crosstalk with EGFR raised PI3K/AKT/NF-kappaB signalling and IL-6 secretion that promoted metastasis in vitro and in vivo.
- Evidence
- Emerging
Cite this record: https://thecellwell.org/studies/HH-78939
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