CellWell record HH-78278
The retinol-metabolizing enzyme DHRS3 coordinates antigen presentation, endothelial stability, and cholesterol metabolism to suppress hepatocellular carcinoma progression
Hongtao Hu; Lidan Zhang; Jiawen Gu; Jialun Zhang; Ying Lu; Kai Zhang; Chenhao Shi; Hang Gao; Siyue Lou; Haixin Qin; Huajun Zhao
2026
In plain language
DHRS3 was upregulated in hepatocellular carcinoma and linked to better prognosis by enhancing antigen presentation and suppressing metastasis, while also driving proliferation through cholesterol metabolism that atorvastatin reversed.
- Evidence
- Emerging
Cite this record: https://thecellwell.org/studies/HH-78278
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