CellWell record HH-78237
Tryptophan-Serotonin-Melatonin Pathway as a Contributor to Changes in Mood and Cognitive Functions Induced by Sleep Deprivation
Marcin Sochal; Aleksandra Wojtera; Marta Ditmer; Agata Gabryelska; Aleksandra Tarasiuk-Zawadzka; Szymon Turkiewicz; Filip Franciszek Karuga; Jakub Fichna; Piotr Białasiewicz
International Journal of Molecular Sciences · 2026
In plain language
In 80 healthy adults, acute sleep deprivation decreased tryptophan and melatonin, and among non-responders serotonin rose while melatonin fell, with SERT mRNA changes correlating with Stroop and trail-making performance.
- Evidence
- Emerging
Cite this record: https://thecellwell.org/studies/HH-78237
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