CellWell record HH-77665
Improvement of glucose homeostasis during leptin treatment does not alter the intestinal microbiome in male diabetic UC Davis type-2 diabetes mellitus rats
Manuel MartÃnez-Ruiz; Leslie Tabor-Simecka; James L Graham; Christopher Randolph; Renee Fox; Renny Lan; Lindsay Pack; Tanya LeRoith; Kimber L Stanhope; Laxmi Yeruva; Peter J Havel; Brian D Piccolo
2026
In plain language
In 24 male diabetic UCD-T2DM rats given 0.5 mg/kg leptin or buffer daily for 4 weeks, glucose homeostasis and insulin sensitivity improved but gut microbiota composition and gut permeability were unchanged.
- Evidence
- Emerging
Cite this record: https://thecellwell.org/studies/HH-77665
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