Studies

CellWell record HH-77464

Depression as a prognostic factor for conversion from mild cognitive impairment to all-cause dementia and Alzheimer's disease: a systematic review and meta-analysis of longitudinal studies

Madina Kassymzhanova; Kuanysh Shonbay; Olga M Shikhova; Natalya Raspopova; Indira Karibayeva

2026

In plain language

Pooling 17 longitudinal cohorts, baseline depression in mild cognitive impairment was associated with higher risk of progression to dementia (adjusted HR 1.21), but heterogeneity was extreme and certainty rated very low.

Evidence
Established

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