CellWell record HH-77404
Keratin 20 deficiency phenocopies human UAB and drives bladder fibrosis via a mechanotransduction-TGF-β axis
Jun Jiang; Yongjia Bao; Tao Huang; Hanbo Zhang; Wensu Ma; Junwei He; Xianbin Duan; Chenxi Mo; Rui Guo; Jingjie Chen; Fang Yan; Jiehui Chen; Xing Liu; Yichen Huang; Fang Chen; Jiasheng Chen; Congcong Dong; Chunming Guo
2026
In plain language
Deleting urothelial keratin 20 in mice produced urinary retention and underactive bladder, weakened umbrella cell load bearing, activated Yap and TGF-beta signalling, and an Alk4/5/7 inhibitor partly reversed the fibrosis.
- Evidence
- Emerging
Cite this record: https://thecellwell.org/studies/HH-77404
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