CellWell record HH-77313
Early risperidone exposure impairs cognitive function by perturbation of the gut microbiome and bile acids/tyrosine-PTP1B axis
Ye H; Yang X; Zheng M; Dong W; Chen X; Chen J; Hu M; Zhou M; Zheng P; Shen L; Wu Y; Zheng K; Huang XF; Yu Y
Microbiome ยท 2026
In plain language
Early-life risperidone impaired cognition and hippocampal dendritic architecture in mice through gut dysbiosis, with reduced brain tauroursodeoxycholic acid and accumulated p-cresol; fecal transplants reproduced the deficits and neuronal PTP1B knockout prevented them.
- Evidence
- Emerging
Cite this record: https://thecellwell.org/studies/HH-77313
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