CellWell record HH-77168
ortho-Substituents govern aryl aldehyde reactivity: toward lysine-targeted, tunable inhibitors of glucose-6-phosphate dehydrogenase
Bronwyn E Rowland; Kelsey D Roy; Adil Alkaş; Mirele Barsoum; Tangweth Kuot; Jesse C Fuller; Adrien J Naudet; Elisa Ospanow; David L Jakeman
2026
In plain language
Across a panel of aryl aldehydes, ortho-substituents governed imine formation with a lysine surrogate, and reactivity correlated with glucose-6-phosphate dehydrogenase inhibitory potency but not with reversibility.
- Evidence
- Emerging
Cite this record: https://thecellwell.org/studies/HH-77168
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