CellWell record HH-76666
TNF-α/PAD4 axis drives hyperhomocysteine-induced white matter injury after acute ischemic stroke
Wei-Hong Du; Hui Guo; Yi-Hui Wang; Xiao-Yan Hu; Jia-Ning Zhang; Chun Guo; Pan-Pan Geng; Yu-Ji Wang; Xin-Chun Jin
2026
In plain language
In mouse stroke models and cell culture, high homocysteine impaired oligodendrocyte precursor differentiation via TNF-alpha and PAD4, and the PAD4 inhibitor YW3-56 promoted differentiation and white matter repair.
- Evidence
- Emerging
Cite this record: https://thecellwell.org/studies/HH-76666
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