Studies

CellWell record HH-76569

Predicting stress response trajectories: Differential contributions of limbic and prefrontal regions to cortisol and affective responses

Renée Lipka; Ludwig Kreuzpointner; Christoph Bärtl; Marina Giglberger; Julian Konzok; Hannah L Peter; Nina Speicher; Lea Waller; Brigitte M Kudielka; Stefan Wüst; Henrik Walter; Gina-Isabelle Henze

2026

In plain language

In 281 healthy adults exposed to a scanner stress task, larger amygdala and hippocampus volumes predicted cortisol hyper-response trajectories, while medial orbitofrontal measures instead tracked negative affect profiles.

Evidence
Emerging

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