CellWell record HH-76294
Pan-repository analysis reveals a drug-activating function of microbial bile acid conjugation
Vincent Charron-Lamoureux; Patricia Kelly; Simone Zuffa; Abubaker Patan; Marta Sala-Climent; Corinn Walker; Haoqi Nina Zhao; Shipei Xing; Harsha Gouda; Julius Agongo; Erin Reilly; Lina Sallam; Selene F.H. Shore; Subhomitra Ghoshal; Anika Harpavat; Marudhu Pandiyan Murugesan; Swara Yadav; James Versalovic; Vlad Orlovsky; Yasin El Abiead; Kine Eide Kvitne; Janet Markle; Grant Norton; Gregory Walker; Michael Lee; Zhewen Hu; Marvic Carrillo Terrazas; David Zong; Amir Zarrinpar; Manuela Raffatellu; Anthony Martin; Loryn Chin; Suzanne Devkota; Antonio Gonzalez; Gail Ackermann; Lucas Patel; Yuhan Weng; Rob Knight; Richard Russell; Richard Hansen; Vaios Svolos; Konstantinos Gkikas; Nicholas J.W. Rattray; Dionicio Siegel; Karsten Zengler; Maribeth Nicholson; Hiutung Chu; Andrew Patterson; Monica Guma; Richard Kellermayer; Melinda Engevik; Thomas Horvath; Konstantinos Gerasimidis; Pieter Dorrestein
2026
In plain language
Mining public mass spectrometry repositories found conjugates of the anti-inflammatory drug 5-aminosalicylic acid with bile acids only in treated individuals, and cholyl-5-ASA reduced colitis pathology in mice while activating PPAR-gamma.
- Evidence
- Emerging
Cite this record: https://thecellwell.org/studies/HH-76294
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