CellWell record HH-74872
The pentose phosphate pathway contributes to excess lactate production in radiation-induced fibroblast to myofibroblast transdifferentiation
Josly Pierre-Louis Odoom; Sarah V Camus; Mark Sfeir; Yang Yue; L Ashley Cowart; Margaret A T Freeberg; Thomas H Thatcher; Patricia J Sime
2026
In plain language
In cultured human lung fibroblasts and a mouse model, radiation upregulated glycolysis and the pentose phosphate pathway, and blocking glucose-6-phosphate dehydrogenase markedly reduced myofibroblast transition, lactate and fibronectin.
- Evidence
- Emerging
Cite this record: https://thecellwell.org/studies/HH-74872
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