CellWell record HH-74844
Spatial mapping of CoQ10 repletion by BPM31510 in a genetic mouse model (Coq4F147C) of coenzyme Q deficiency
Eliana Barriocanal-Casado; Sylwia A Stopka; Alba Pesini; Juan J Aristizabal-Henao; Srada Karmacharya; Devon Van Cura; Ryan Zhang; Kelsey R Nickerson; Kashni Grover; Oksana Zavidij; Sarah R Wessel; Niven R Narain; Vijay Modur; Stephane Gesta; Michael A Kiebish; Catarina M Quinzii
2026
In plain language
In Coq4 F147C knock-in mice given 200 mg/kg lipid nanoparticle CoQ10 every two days for 13 days, oxidized CoQ10 increased across brain, heart, kidney and muscle, with imaging showing cerebellar and renal cortex restoration.
- Evidence
- Emerging
Cite this record: https://thecellwell.org/studies/HH-74844
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