CellWell record HH-64413
Association between proton pump inhibitor use and upper gastrointestinal cancer: A matched case-control study accounting for reverse causation and confounding by indication
Ibrahim O Sawaid; Zohar Din; Efrat Golan; Eytan Ruppin; Avivit Golan-Cohen; Ilan Green; Eugene Merzon; Shlomo Vinker; Abraham O Samson; Ariel Israel
2026
In plain language
In 875 adults with upper GI cancer matched to 8,750 controls in Israel, apparent links to proton pump inhibitor use disappeared after adjusting for symptom diagnoses and excluding the final pre-diagnosis year. Remote use was linked to lower odds.
- Evidence
- Emerging
- Design
- Case-control study
Cite this record: https://thecellwell.org/studies/HH-64413
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