Studies

CellWell record HH-589017

Progesterone-KISS1 axis impairs amniotic epithelial cell function and promotes premature rupture of membranes

Shuguang Su; Qiantao Ye; Feilong Chen; Qin Tian; Caixia Gan; Yanqiu Li

2026

In plain language

Fetal membrane proteomics, a mouse model and human amniotic cell experiments linked a reciprocal progesterone-KISS1 relationship to amniotic epithelial cell function, with KISS1 upregulated in premature rupture of membranes.

Evidence
Emerging
Design
Primary research (design unspecified)

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