CellWell record HH-587125
Reverse genetics in humanized mice reveals CARD8-mediated pyroptosis causing pancytopenia in human DPP9 deficiency
Tianli Xiao; J Richard Brewer; Maximillian Carlino; Ailin Han; Yamato J Takabe; Chia-Yi Lee; Fengrui Zhang; Mi Chen; Holly Nicole Blackburn; Amin H Nassar; Qiankun Wang; Kristen Brennand; Liang Shan; Esen Sefik; Diane S Krause; Richard A Flavell
2026
In plain language
In humanized mice, CRISPR deletion of DPP9 in human blood stem and progenitor cells caused cytopenia through CARD8 inflammasome-driven pyroptosis, independent of NLRP1.
- Evidence
- Emerging
- Design
- Primary research (design unspecified)
Cite this record: https://thecellwell.org/studies/HH-587125
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