CellWell record HH-586625
Novel 1,4-Diazepane derivatives as amyloid-beta (Aβ) aggregation inhibitors
Rahul C. Karuturi; Ahmed A. Hefny; Arash Shakeri; Praveen P. N. Rao
Frontiers in Chemistry · 2026
In plain language
In laboratory assays, 1,4-diazepane derivatives 4k and 4l partly inhibited both amyloid-beta 42 and 40 aggregation at 25 µM, and 4k -- m reduced Aβ42-induced toxicity in cultured mouse hippocampal cells.
- Evidence
- Emerging
- Design
- Primary research (design unspecified)
Cite this record: https://thecellwell.org/studies/HH-586625
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