CellWell record HH-584099
A dual-targeting mRNA lipid nanoparticle restores ABCA1-dependent cholesterol homeostasis to promote repair of age-related bone defects
Mengze Cheng; Kun Xi; Zhengxia Ni; Lingjun Wang; Jincheng Tang; Wei Wang; Ziang Li; Liang Zhou; Xinzhao Jiang; Jie Wu; Qiangqiang Guo; Yiwei Zhu; Zhengjie Tao; Tianyi Li; Changdong Cui; Wenguo Cui; Liang Chen; Yong Gu
2027
In plain language
In aged rats with bone defects, a dual-targeted mRNA lipid nanoparticle was associated with improved bone regeneration and alleviated senescence in aged bone marrow stem cells.
- Evidence
- Emerging
- Design
- Primary research (design unspecified)
Cite this record: https://thecellwell.org/studies/HH-584099
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