CellWell record HH-580099
Antigen-presenting cancer-associated fibroblasts in murine pancreatic tumors differentially regulate T-cell phenotype and function
Maru SY; Wetzel M; Mitchell JT; Gross NE; Andaloori L; Howe K; Kartalia E; Mo G; Leatherman J; Ho WJ; Fertig EJ; Kagohara LT; Pearce EJ; Jaffee EM
Journal of immunology (Baltimore, Md. : 1950) ยท 2026
In plain language
In mice with pancreatic tumors, reducing antigen-presenting fibroblasts impaired checkpoint blockade response, while fibroblasts in resistant tumors promoted more immunosuppressive regulatory T cells via CCL22.
- Evidence
- Emerging
- Design
- Primary research (design unspecified)
Cite this record: https://thecellwell.org/studies/HH-580099
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