CellWell record HH-5614
The structure and function of the ATP-sensitive K+ channel in insulin-secreting pancreatic beta-cells
Ashcroft FM, Gribble FM
Diabetologia ยท 1999
In plain language
Pancreatic beta cells sense rising blood glucose through a fall in the ATP-to-ADP ratio, which closes ATP-sensitive potassium channels, depolarizes the cell, and triggers the calcium influx that releases insulin.
- Evidence
- Established
- Design
- Expert review
Cite this record: https://thecellwell.org/studies/HH-5614
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