CellWell record HH-553275
C34-18 The Role of Nrf2 in Regulating Neutrophilic Airway Inflammation via the Nlrp3 Inflammasome
K. Kawashima; Y. Morishima; K. Yoshida; K. Ueda; K. Nishino; S. Matsumura; C. Sakai; Y. Yabuuchi; K. Yazaki; M. Matsuyama; T. Kiwamoto; Y. Ishii
American Journal of Respiratory and Critical Care Medicine · 2026
In plain language
In house-dust-mite asthma mice, Nrf2 deficiency increased NLRP3-caspase-1-IL-1β signaling and neutrophilic airway inflammation, and sulforaphane activation of Nrf2 reduced this inflammation in wild-type mice.
- Evidence
- Emerging
- Design
- Primary research (design unspecified)
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