CellWell record HH-5432
Lithium regulates adult hippocampal progenitor development through canonical Wnt pathway activation
Wexler EM; Geschwind DH; Palmer TD
Molecular Psychiatry ยท 2008
In plain language
Lithium expanded adult hippocampal progenitor pools and promoted their conversion into neurons at therapeutically relevant concentrations, acting through GSK-3beta downregulation and elevated beta-catenin signaling.
- Evidence
- Emerging
- Studied in
- Human, Animal, Cell / in vitro
Cite this record: https://thecellwell.org/studies/HH-5432
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