CellWell record HH-5429
Lithium induces autophagy by inhibiting inositol monophosphatase
Sarkar S; Floto RA; Berger Z; Imarisio S; Cordenier A; Pasco M; Cook LJ; Rubinsztein DC
Journal of Cell Biology ยท 2005
In plain language
Lithium inhibited inositol monophosphatase, lowered IP3, and induced autophagy through a novel mTOR-independent pathway, enhancing clearance of aggregate-prone proteins in cell and animal models.
- Evidence
- Established
- Studied in
- Human, Animal, Cell / in vitro
Cite this record: https://thecellwell.org/studies/HH-5429
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