CellWell record HH-5428
Lithium and bipolar mood disorder: the inositol-depletion hypothesis revisited
Berridge MJ; Downes CP; Hanley MR
Molecular Psychiatry ยท 2005
In plain language
Lithium uncompetitively inhibits inositol monophosphatase, depleting free myo-inositol and dampening phosphoinositide signaling, a proposed mechanism for mood stabilization that remains scientifically unproven after decades of study.
- Evidence
- Contested
- Design
- Expert review
Cite this record: https://thecellwell.org/studies/HH-5428
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