CellWell record HH-538643
Structural and functional modulation of human kynurenine aminotransferase I enhances selenium-driven redox metabolism for cancer therapy
Selvam AK; Sun R; Sandalova T; Salter H; Achour A; Björnstedt M
Redox biology · 2026
In plain language
Site-directed mutations in human kynurenine aminotransferase 1 enhanced Se-methylselenocysteine metabolism, increasing its cytotoxicity five- to 30-fold versus wild-type enzyme in hepatocellular carcinoma cell lines.
- Evidence
- Emerging
- Design
- Primary research (design unspecified)
Cite this record: https://thecellwell.org/studies/HH-538643
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