CellWell record HH-512970
Blocking hepatocyte retinoic acid signaling increases hepatic retinol-RBP4 secretion and disrupts vitamin A homeostasis in mice.
Emily S. Sugars; Olivia S. Sadilek-Thring; Samantha Kinney; Mitchell A.G. Pearson; Stephane L. Bourque; Robin D. Clugston
Journal of Nutritional Biochemistry ยท 2026
In plain language
Blocking retinoic acid signaling in mouse hepatocytes unexpectedly raised circulating retinol and RBP4, whereas diet-induced vitamin A deficiency lowered plasma retinol-RBP4, showing the two conditions affect hepatic secretion differently.
- Evidence
- Emerging
- Design
- Primary research (design unspecified)
Cite this record: https://thecellwell.org/studies/HH-512970
Produced by the CellWell Research Engine, custom software owned and operated by CellWell and The Holistic Hub. All rights reserved. This analysis, its indexing and its evidence classifications are proprietary. Any use, republication or onward sharing must credit CellWell Research Engine (thecellwell.org) as the source.
This is an educational research library, not medical advice. Nothing here may be used to diagnose, treat, cure, or prevent any disease. Always consult a qualified professional.