CellWell record HH-512161
Smooth muscle cell estrogen receptor alpha promotes arterial stiffness in the absence of estradiol
Casey G. Turner; Jacqueline Matz; Jade Breton; Karla de Oliveira; Rachel Kenney; Jennifer Vorn; Michelle J Zhao; Jaime Ibarrola; Qing Richard Lu; Gregory Martin; Zhe Sun; Iris Zamir Jaffe
bioRxiv (Cold Spring Harbor Laboratory) ยท 2026
In plain language
In mice, ovariectomy increased aortic stiffness and fibrosis, estradiol prevented this, and deleting estrogen receptor alpha in smooth muscle cells blocked aging-related stiffening in females and partly in males.
- Evidence
- Emerging
- Design
- Preprint
Cite this record: https://thecellwell.org/studies/HH-512161
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