CellWell record HH-501043
Role of Complement Component 9 in Bone Health: Causal Evidence in Humans and Mechanistic Studies in Mice
Claes Ohlsson; Anna E Törnqvist; Karin H Nilsson; Maria Nethander; Jianyao Wu; Lei Li; Antti Koskela; Sofia Movérare-Skrtic
2026
In plain language
Genetically higher circulating complement C9 was causally linked to greater fracture risk in humans, while C9-deleted mice showed sex-specific and site-specific changes in vertebral trabecular bone.
- Evidence
- Emerging
- Design
- Primary research (design unspecified)
Cite this record: https://thecellwell.org/studies/HH-501043
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