Studies

CellWell record HH-500524

Safety of Potassium-Competitive Acid Blockers Compared With Proton Pump Inhibitors in Patients With Gastroesophageal Reflux Disease and Peptic Ulcer Disease: A Systematic Review and Meta-Analysis

Jang Y; Park J; Kang D; Kim JH; Choi HS; Jeon HL; Lee H

Journal of gastroenterology and hepatology ยท 2026

In plain language

In a meta-analysis of ten trials and one observational study, potassium-competitive acid blockers showed adverse event risk comparable to proton pump inhibitors, but with greater serum gastrin elevation and a threefold higher fracture rate.

Evidence
Established
Design
Meta-analysis

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