CellWell record HH-499124
The effect of non-tobacco nicotine on bone healing: a systematic review and application to total joint arthroplasty
Levi M Travis; John C Cacciatore; J Alfredo Schuster; Faaris Khan; Jonathan M Stern; Maya R Moore; Layal Hneiny; Victor H Hernandez; Colin A McNamara
2026
In plain language
This systematic review of 62 studies found nicotine, independent of tobacco smoke, has a dose-dependent effect on bone healing and implant integration, mostly shown in animal and in vitro studies.
- Evidence
- Established
- Design
- Systematic review
Cite this record: https://thecellwell.org/studies/HH-499124
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