CellWell record HH-496563
Glucose controls metallothionein 1 gene expression in pancreatic islets via a mechanism involving cellular metabolism, granular zinc and the zinc transporter ZnT8 in rat and mouse
Cheng R; Zhao C; Guan N; Yue L; Ma D; Ka M; Lee K; Laybutt DR; Jonas JC; Bensellam M
Diabetologia · 2026
In plain language
Low blood glucose in fasted rats and insulin-pump mice raised islet Mt1 expression, and this rise required functional ZnT8, since it was absent in Znt8-knockout islets.
- Evidence
- Emerging
- Design
- Primary research (design unspecified)
Cite this record: https://thecellwell.org/studies/HH-496563
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