CellWell record HH-492892
Choline metabolism drives metastasis in BRCA1-deficient ovarian cancers by activating FAM3C
Cong Wang; Xuexia Xie; Jiahuang Li; Jiawei Zhu; Binghe Sun; Yue Wu; Wanying Zhang; Dake Li; Guo Chen
2026
In plain language
Loss of BRCA1 increased choline uptake through the transporter CTL4, which was linked to ovarian cancer metastasis, and inhibiting CTL4 reduced the metastatic potential of BRCA1-deficient cells.
- Evidence
- Emerging
- Design
- Primary research (design unspecified)
Cite this record: https://thecellwell.org/studies/HH-492892
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