Studies

CellWell record HH-49271

Associations of Plasma Homocysteine Reflecting Vitamin B12 and Folate Status with Fatigue-Related Outcomes in Healthy Adults

Hiroaki Kanouchi; Ayaka Yamamoto; Akiko Kuwabara; Shigeo Takenaka; Eiji Nishikubo; Yukihiro Nomura; Takehiro Naruto; Kyosuke Watanabe; Kei Mizuno; Yasuyoshi Watanabe

2026

In plain language

In 602 healthy adults, higher homocysteine tertiles were linked to more physical fatigue in men and lower motivation in women, though the effect vanished when homocysteine was analyzed continuously.

Evidence
Emerging
Design
Primary research (design unspecified)

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