CellWell record HH-492243
EphB1-Mediated Transient Blood-Brain Barrier Opening Facilitates a Ferritin-Based Nanotherapeutic for Alzheimer's Disease
Shilin Wen; Jingjing Gao; Zhixian Wang; Qiumin Ma; Xiao-Ling Xu; Jianer Chen
2026
In plain language
In AD model mice, apoferritin nanoparticles carrying donepezil transiently opened the blood-brain barrier via EphB1, reduced amyloid plaque burden and neuroinflammation, and improved cognition compared with free donepezil.
- Evidence
- Emerging
- Design
- Primary research (design unspecified)
Cite this record: https://thecellwell.org/studies/HH-492243
Produced by the CellWell Research Engine, custom software owned and operated by CellWell and The Holistic Hub. All rights reserved. This analysis, its indexing and its evidence classifications are proprietary. Any use, republication or onward sharing must credit CellWell Research Engine (thecellwell.org) as the source.
This is an educational research library, not medical advice. Nothing here may be used to diagnose, treat, cure, or prevent any disease. Always consult a qualified professional.