CellWell record HH-492242
Lipid-anchored melanotransferrin mediates transferrin-independent iron uptake and ferritin storage in mammals
Mei Mei Tian; Jacqueline W C Tiong; Reinhard Gabathuler; Garnet Martens; Elaine C Humphrey; Wilfred A Jefferies
2026
In plain language
In human melanoma cells, GPI-anchored melanotransferrin took up transferrin-independent iron through caveolae-dependent internalization and Rab5 endosomal trafficking, with the iron then directed to ferritin storage.
- Evidence
- Emerging
- Design
- Primary research (design unspecified)
Cite this record: https://thecellwell.org/studies/HH-492242
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