Studies

CellWell record HH-48676

Endocrine toxicities in immune checkpoint inhibitors and tyrosine kinase inhibitors combined treatment: from clinical trials to real-life practice

Sabrina Chiloiro; Maria Grazia Maratta; Simone Antonio De Sanctis; Flavia Costanza; Ernesto Rossi; Emanuele Vita; Antonella Giampietro; Francesco Pavese; Olga Martelli; Ida Paris; Antonio Bianchi; Giovanni Schinzari; Laura De Marinis; Anna Fagotti; Giampaolo Tortora; Alfredo Pontecorvi

2026

In plain language

This review found that combined immune checkpoint inhibitor and tyrosine kinase inhibitor cancer treatments can cause endocrine side effects including thyroid dysfunction, adrenal insufficiency, and diabetes, requiring early multidisciplinary monitoring.

Evidence
Established
Design
Systematic review

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