Studies

CellWell record HH-484316

The therapeutic readiness of probiotics in major depressive disorder: A systematic review of randomised controlled trials

Dinyadarshini Johnson; Dinesh Sangarran Ramachandram; Jack Doorly; Gerard Clarke; Kok-Gan Chan; Sivakumar Thurairajasingam; Learn-Han Lee; Vengadesh Letchumanan

2026

In plain language

Across 13 randomized trials of 437 adults with major depressive disorder, most reported improved depressive symptoms, with multi-strain probiotic formulations showing the most consistent benefit.

Evidence
Established
Design
Systematic review

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