Studies

CellWell record HH-47889

Nutritional Interventions for Perimenopausal Anxiety and Depression Targeting Tryptophan and GABA Pathways: A Narrative Review

Huiying Zhao; Wei Wu

2026

In plain language

This narrative review proposes that estrogen fluctuations during perimenopause alter gut microbiota, tryptophan metabolism and GABA synthesis, and discusses nutritional strategies targeting these pathways, though efficacy in perimenopausal women remains unestablished.

Evidence
Emerging
Design
Expert review

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