CellWell record HH-47847
Lithium inhibits tryptophan catabolism via the inflammation-induced kynurenine pathway in human microglia
Göttert R; Fidzinski P; Kraus L; Schneider UC; Holtkamp M; Endres M; Gertz K; Kronenberg G
Glia · 2022
In plain language
In cultured human microglia, lithium reduced interferon-gamma-induced activity of the tryptophan-degrading enzyme IDO1 and increased the anti-inflammatory cytokine IL-10, suggesting a mechanism for lithium's mood-stabilizing effects.
- Evidence
- Emerging
- Design
- Primary research (design unspecified)
Cite this record: https://thecellwell.org/studies/HH-47847
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