CellWell record HH-472843
Selenium-Thioredoxin Axis Contributes to Ferroptosis Resistance in Pancreatic Cancer Cells
Arslan Amer; Micah Idowu; Aqsa Ahsan; A. Abbas; T. Alothaim; Xiao-Hu Tang
International Journal of Molecular Sciences ยท 2026
In plain language
In epithelial-type pancreatic cancer cells, resistance to ferroptosis depended on thioredoxin reductases TrxR1 and TrxR2, and selenium's protection worked through this pathway independently of GPX4 and Sepp1.
- Evidence
- Emerging
- Design
- Primary research (design unspecified)
Cite this record: https://thecellwell.org/studies/HH-472843
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