Studies

CellWell record HH-472049

Hypomagnesemia: the 12th pitfall in interpreting hyperlactatemia in sepsis

Thanh Luan Nguyen; Phuc Tuong Pham; Van Hoa Ho

Emergency and Critical Care Medicine ยท 2026

In plain language

This commentary argues that low magnesium impairs pyruvate dehydrogenase activity and can raise lactate independent of poor perfusion, citing studies linking hypomagnesemia to lactic acidosis in sepsis, so magnesium should be considered when interpreting lactate.

Evidence
Emerging
Design
Primary research (design unspecified)

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