CellWell record HH-471996
Mitochondrial Dysfunction fuels Osimertinib Resistance via the Pyruvate-Acetaldehyde-Acetate (PAA) Metabolic Bypass in EGFR-Mutant NSCLC
Elena Levantini
2026
In plain language
In drug-resistant EGFR-mutant lung cancer cells, mitochondrial dysfunction was linked to resistance through an alternative pyruvate-acetaldehyde-acetate pathway, and disabling Aldh2 restored drug sensitivity.
- Evidence
- Emerging
- Design
- Preprint
Cite this record: https://thecellwell.org/studies/HH-471996
Produced by the CellWell Research Engine, custom software owned and operated by CellWell. All rights reserved. This analysis, its indexing and its evidence classifications are proprietary. Any use, republication or onward sharing must credit CellWell Research Engine (thecellwell.org) as the source.
This is an educational research library, not medical advice. Nothing here may be used to diagnose, treat, cure, or prevent any disease. Always consult a qualified professional.