CellWell record HH-47153
Modeling bipolar disorder in mice by increasing acetylcholine or dopamine: chronic lithium treats most, but not all features
Jordy van Enkhuizen; Morgane Milienne-Petiot; Mark A Geyer; Jared W Young
2015
In plain language
In mice, a drug that raised acetylcholine caused depression-like immobility and a dopamine transporter inhibitor caused mania-like hyperactivity, with chronic lithium normalizing the depression-like behavior but only partly reducing the mania-like behavior.
- Evidence
- Emerging
- Design
- Animal study
Cite this record: https://thecellwell.org/studies/HH-47153
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