CellWell record HH-47129
Intranasal Delivery of Lithium Salt Suppresses Inflammatory Pyroptosis in the Brain and Ameliorates Memory Loss and Depression-like Behavior in 5XFAD Mice
Piplu Bhuiyan; Wenjia Zhang; Ge Liang; Bailin Jiang; Robert Vera; Rebecca Chae; Kyulee Kim; Lauren St Louis; Ying Wang; Jia Liu; De-Maw Chuang; Huafeng Wei
2025
In plain language
In 5XFAD Alzheimer's model mice, intranasal lithium chloride reduced brain inflammation and pyroptosis markers and improved both memory loss and depression-like behavior, without affecting thyroid or kidney blood markers.
- Evidence
- Emerging
- Design
- Primary research (design unspecified)
Cite this record: https://thecellwell.org/studies/HH-47129
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