Studies

CellWell record HH-47088

The 25-Year Evolution of Lithium as a Disease-Modifying Agent in Dementia: A Narrative Review

Moore GJ; Bose N; Henter ID; Manji HK

JAMA psychiatry ยท 2026

In plain language

This narrative review describes preclinical and imaging evidence that chronic and low-dose lithium supports neuronal survival and preserves brain structure, and proposes a clinical trial of low-dose lithium orotate for mild cognitive impairment.

Evidence
Emerging
Design
Narrative review

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