Studies

CellWell record HH-469347

Genetic Determinants of Sex Hormones and SHBG Across Menopausal Stages and Hormone Replacement Therapy Use: Implications for Endometrial Cancer Risk

Yaqi Alexandra Deng; Åsa Johansson; Torgny Karlsson; Simon Henning

2026

In plain language

Mendelian randomization in UK Biobank women found that higher SHBG was inversely associated with endometrial cancer risk outside hormone therapy, while the testosterone link weakened after adjustment.

Evidence
Emerging
Design
Preprint

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