CellWell record HH-468329
1089-OR: The Antiviral Response Proteins IFITM2/IFITM3 Bind to the Insulin Receptor and Drive Both Ligand and Tyrosine Kinase-Dependent and -Independent Functions
Anindya Ghosh; V. Muñoz; Yoshiyuki Watanabe; Marsel Lino; C. R. Kahn
Diabetes · 2026
In plain language
In cultured preadipocytes, the immune protein IFITM3 bound the insulin receptor through amino acids 72-92 and, when present, restrained insulin-stimulated AKT phosphorylation while suppressing apoptosis.
- Evidence
- Emerging
- Design
- Primary research (design unspecified)
Cite this record: https://thecellwell.org/studies/HH-468329
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